GO:0035333 biological_process Notch receptor processing, ligand-dependent
| PAG Title | GO:0035333 biological_process Notch receptor processing, ligand-dependent |
| PAG ID | TAX022823 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). |
| Species | Homo sapiens |
| nCoCo Score | 1,718 |
| Base PAG ID | TAX022823 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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